Implant To Pull The Plug On Migraine Pain

implant to cut off pain

 

Implant That Cuts Off Pain (1)

Another hand-me-down tool in the pain management kit for migraineurs but one that shows promise for the chronic migraineur. Patients who have tried almost all routes to seek relief from popping in painkillers and taking prescription opoids, having botox injected, trying hypnosis and biofeedback as well as other alternative therapies like shiastu and autogenic training but have turned to the doctor dismayed with the results now have hope. There appears to be one last technique/tool that some doctors may suggest to such patients. It is not meant for all migraineurs and is suggested on a case to case basis. It is yet to be approved by the Food and Drug Administration (FDA).

The device was designed for patients of chronic back pain. But now it is holding hope for migraineurs who have tried everything and have no other corner to turn. According to Jenny Bruner who had been dealing with the onslaught of pain for many years, “I went to a neurologist. I was hospitalized. Then they put me on preventative medicines.  We tried acupuncture, even botox. I tried biofeedback, and nothing was working. I didn’t see any hope.  It was so frustrating just living in constant pain. It’s unbearable because you are not able to eat because you are nauseated all the time.” (2) During her years with the neurological disease she tried as many as 62 different medications with little or no help from any.

However, she did in the course come across a management technique involving neuro-stimulation. The treatment was called Transforma and it gave her considerable relief like no other technique or medication had.

The system involved the implantation of tiny leads just below the skin. These sub-cutaneous leads are connected to a battery pack. This battery is implanted in the lower back of the patients. The battery sends electrical pulses of very low voltage to the areas of the brain that process pain and is involved in pain signalling. The beauty of the system is that the migraineur can adjust the voltage strength according to her/his needs or the level of pain being experienced in a migraine episode. The electrical pulses feel like a mild massage.

According to migraine specialist Dr. Jack Chapman, “We are turning on a small electrical signal to the nerve to basically shut off or change that nerves transmission of the pain that people interpret as a headache.” (3) To Bruner, this has been a life-changing treatment. She has retrieved bits of life that she had to let go off.

SOURCES

  1. Image Credit: Asian Girl With Headache; tokyoboy; Freedigitalphotos.net; web October 2013; http://www.freedigitalphotos.net/images/Healthcare_g355-Asian_Girl_With_Headache_p86098.html
  2. Relief for migraine sufferers thanks to small electronic device; ClickOrlando.com; Web October 2013; http://www.clickorlando.com/news/relief-for-migraine-sufferers-thanks-to-small-electronic-device/-/1637132/22282540/-/t3xan8z/-/index.html
  3. New treatment helping people with migraines; WNDU.com; Web October 2013; http://www.wndu.com/news/specialreports/headlines/New-treatment-helping-people-with-migranes-226347731.html

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OptiNose – New Migraine Treatment: Data Presented At IHC 2013

TE_optinoseOptiNose’s Breath Powered Nasal Delivery Device (1)

Drug delivery technology corporation OptiNose Inc. has presented results of a pivotal phase III TARGET study at the International Headache Congress at Boston comparing both the efficacy and the safety of it’s newly developed technology – the OptiNose Breath Powered nasal delivery device with other drug delivery systems and placebos. The abstracts are to be published in Cephalalgia, the Journal of the International Headache Society

The breath-powered device containing low dose sumatriptan was used to deliver the drug in patients experiencing moderate to severe migraine pain, and then compared to placebo administered via the same route later.

According to Ramy A. Mahmoud, M.D., M.P.H., Chief Operating Officer of OptiNose, “Various data we are presenting today will highlight how this novel delivery technology improves the delivery of medicine to hard-to-reach regions deep in the nasal cavity, how it can produce fast and efficient absorption of medicine into the blood, and how effective treatment with this technology can be. There are nearly 30 million migraine sufferers in the United States and many will be able to benefit from a new low-dose treatment that can rapidly provide effective pain relief with few adverse events.” (2)

Sections discussed in the International Headache Congress 2013 included:

  • Efficacy and Safety of a Novel Breath Powered Powder Sumatriptan Intranasal Treatment for Acute Migraine;
  • Data from a randomized, single-dose, four-way cross-over study assessing the absorption into the blood of sumatriptan intranasal powder administered using the  Breath Powered OptiNose drug delivery device compared to Imitrex® subcutaneous injection, Imitrex nasal spray and Imitrex oral tablets in healthy adult volunteers.
  • A review of evidence for human in vivo drug deposition patterns in different regions of the nose with devices intended to provide reliable and efficient drug delivery to upper/posterior nerve structures deep in the nasal cavity.

To know more about the TARGET study, please visit the OptiNose website link given below. (3)

SOURCES:

  1. Image Credit: Nansen Neuroscience Netwrok; Optinose: Novel Nasal Drug Delivery device; Web June 2013; http://www.nansenneuro.net/news/member-news/285-novel-nasal-drug-delivery-device.html
  2. OptiNose AS to Present Data Highlighting New Migraine Treatment at International Headache Congress; BioSpace.com; Web June 2013; http://www.biospace.com/news_story.aspx?StoryID=301426&full=1
  3. A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Evaluating The Efficacy And Safety Of A Single 20 Mg Dose Of Sumatriptan Powder Delivered Intranasally With The Bi-Directional Device In Adults With Acute Migraine With Or Without Aura; TARGET Phase III Study; Optinose.com; Web June 2013; http://www.optinose.com/clinical-trials/target-clinical-trial-for-migraine

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