New Research From AAN: Your Pain Threshold Directly Links To Cortical Thickness

Brain Cortical Thickess

Brain Cortical Thickness Directly Implicated In Feeling Migraine Pain (1)

A new study presented by Mayo Clinic at the AAN’s (American Academy of Neurology) 67th Annual Meeting was highlighted by the Vice Chair of the Academy. The study clearly demonstrated that there was a direct and positive correlation between the cortical thickness in the brain and the thresholds of pain in migraineurs.

As per the Vice Chair of the AAN, Dr. Rost, who is also the director of acute stroke services at the Massachusetts General Hospital and an associate professor at the Harvard Medical School, “The object of study was to evaluate the cortical thickness in the areas that are potentially associated with pain processing.” (2)

Incidentally, other independent studies conducted previously have also indicated that migraineurs are hypersensitive to perceiving their pain partially because they are over-vigilant to certain painful stimuli and are usually not able to distract themselves from the pain or pain stimuli successfully.

The study examined a total of 63 subjects out of which 31 were migraineurs and the remaining were healthy individuals and formed the control group. Using the T1 sequencing technique in MRIs they studied the cortical thickness of each region of their brains and calculated the relation to the person’s pain threshold.

The values arrived at showed a negative correlation in cortical thickness and pain threshold among non-migraineurs. However, the control group had lower cortical thickness in the area of their interest. On the contrary, migraineurs not only had a positive correlation but had less tolerance to specific pain stimuli. The most significant difference in the cortical thickness between the migraineurs and the control group was found to be in the left superior temporal, anterior parietal regions of the brain. Thus this finding, along with some previous studies form a new approach where the doctors should not only use the old techniques to manage migraines but also apply new one where migraineurs are able to inhibit their pain to a significant extent by distracting themselves from it.

According to Dr. Rost, “This is in face the region of the brain that participates in attention to painful stimulus and orientation to that stimulus. It opens an interesting segue into the dynamic interaction of neurons during a migraine. There is a way to retrain the brain and that plasticity, biofeedback and other therapies, play a role in that.”

SOURCE

  1. Human Brain by Dream Designs via Stock Photo; Freedigitalphotos.net; Web May 2015; http://www.freedigitalphotos.net/images/human-brain-photo-p214120
  2. A New Way To Think About Migraines: Biosciencetechnlogy.com; Web May 2015; http://www.biosciencetechnology.com/articles/2015/05/new-way-think-about-migraines
  3. Correlations between Brain Cortical Thickness and Cutaneous Pain Thresholds Are Atypical in Adults with Migraine; PLOSOne.com; Web May 2015; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099791

Copyrights apply to this blog. Please refer copyright permissions.

Advertisements

Migraining Women Likely To Develop Dementia: Study

Dementia Risk For Migraineurs

 

Migraineurs With Aura Are 48% More Likely To Develop Dementia In Later Life (1)

As if the sustained pounding, debilitating pain, the flurry of traumatic symptoms and ineffective medicines were not enough for migraineurs, studies are now showing that persons who suffer migraines with visual and other aura are 48% more likely to develop dementia as they begin to age than their healthier counterparts! (2)

In part this could be explained by the presence of white matter lesions that the brains of migraineurs are often seemed to have when scanned using an MRI (Magnetic Resonance Imaging).

We know that white matter of the brain consists of nerve fibres (axons) and are surrounded by fat called myelin (3). The main function of the white matter is to transmit signals from one region of the cerebrum to another and between the cerebrum and lower brain centres. Lesions in the white matter interfere with signal transmissions. Damage to this white matter is a common significant factor observed in all those suffering from dementia.

Earlier control tests and those conducted at the Changhua Christian Hospital, Taiwan has already shown that migraineurs are at an exponential risk of diabetes and of developing hypertension, depression and cardiovascular diseases.

However, other studies have shown that the mental status of women with a history of migraine was no different from other women’s, so more research is needed.

SOURCES

  1. Image Credits: Dementia Disease And A Loss Of Brain Function And Memories As Al by David Castillo Dominici: FreeDigitalPhotos.net; Web November 2013; http://www.freedigitalphotos.net/images/dementia-disease-and-a-loss-of-brain-function-and-memories-as-al-photo-p173821
  2. Migraine may be linked to dementia; IOL Lifestyle; Web November 2013; http://www.iol.co.za/lifestyle/migraine-may-be-linked-to-dementia-1.1608597#.UoowF9JmiSo
  3. White matter of the brain; MedlinePlus; Web November 2013; http://www.nlm.nih.gov/medlineplus/ency/article/002344.htm

Copyrights apply to this blog. Please refer copyright permissions.

Migraines Could Lead To White Matter Damage In Brain: New Study

Migraine photo

Abnormalities are common in the signal-sending white matter of migraineurs with aura (1)

A recent analysis of some 19 medical studies put together on migraineurs point that permanent changes likely occur in the brain of those who suffer from migraines and particularly those among them who experience aura – visual or otherwise, before the onset of an attack.

The analysis which was published online in the latest Journal of Neurology concluded that migraineurs with aura were almost two times as likely to have anamolies/abnormalities in the brain structure as those who do not suffer from migraines.

MRIs clearly show white-matter blips and other tissue changes in the migraineurs brain images but how exactly do these neurological variances translate to significant imagery correlate or give a prognosis of progressive deterioration is yet to be seen.

According to Dr. Richard B. Lipton, a neurologist who heads the Montefiore Headache Center in the Bronx, N.Y. “Part of the message I hope to communicate here is: If you have migraine with aura and you have white-matter lesions, they’re probably not a cause of concern.”  (2) However he noted that migraineurs with aura have twice the risk of getting a stroke than non-aura migraineurs

The 19 medical study analysis said the occurrence of tiny lesions that imitate scars left from strokes in aura migraineurs have left them inconclusive because there was no significant evidence of cognitive decline or other neurological symptoms from such lesions or other white-matter anomalies.

In addition, Dr Lipton said that it was good to follow the ‘you never know’ strategy,  further saying, “If you have migraine with aura, certainly you shouldn’t smoke,. Certainly, if you are going to use oral contraceptives, you should use the lowest possible hormonal dose. If you have other stroke risk factors such as hypertension or diabetes or high cholesterol, it becomes particularly important to manage those risk factors.” (2)

What was found to be more disturbing was the uncertainty that surrounds the direction of the correlations. This especially so because it puts forth the reverse question on the table : Is it that the peculiar white-matter phenomena of aura migraineurs on MRI images is what makes for a migraine-prone brain? That is, are the brains of migraine patients different to begin with?

SOURCE:

  1. Image Credits: Sad Middle Aged Woman Suffering From Headache; StockImages; FreeDigitialPhotos.net; Web August 2103; http://www.freedigitalphotos.net/images/Emotions_g96-Sad_Middle_Aged_Woman_Suffering_From_Headache_p150766.html
  2. Migraine could be associated with brain damage, study warns; Los Angeles Times; Web August 2013; http://www.latimes.com/science/sciencenow/la-sci-sn-migraine-brain-damage-20130828,0,7497521.story

Copyrights apply on this blog. Please refer copyright permissions.