Episode Durations & Number Cutbacks With Diamine Oxidase Pills

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Diamine Oxidase Supplements May Reduce The Number, Duration, Intensity of Attacks (1)

Researchers have found that taking diamine oxidase supplements significantly reduces the duration of a migraine episode, especially if the migraine has been brought on by food triggers like cheese, caffeine, red wine etc. They have also observed that there exists a mildly indirect relation between to the total number migraine attacks itself in the mid to long run.

Diamine oxidase (DAO) is an amino acid that helps metabolise (break down) histamines released by our bodies. When we eat foods that we are allergic to (because our body cannot handle it’s digestion for any number of reasons specifically lack of appropriate enzymes) then the body perceives the situation as a threat to it’s well being. As a result it begins an immune response. In such as case histamines are released causing the capillary walls to give more access to proteins and white blood cells to engage with the pathogen/trigger/danger. This increase in histamine triggers migraines.

Histamines are also present in certain foods itself that when consumed raise histamine levels of the body and then trigger a migraine. Thus it is obvious that if migraineurs with food or weather triggers are administered an enzyme (such as DAO) that is responsible for the breakdown of histamines, migraine duration and number of attacks would reduce.

According to Joan Izquierdo, MD, from the Faculty of Health Sciences at the International University of Catalonia and the neurology service at Catalonia General Hospital in Barcelona, Spain, who studied men or women between ages 18 to 60 years old with an attack within the previous 6 months, “We diagnosed 137 patients who have a migraine, of who 119 showed deficits of the activity of the enzyme DAO, around 87% of the total patients that we have studied.” (2)

The study did not take into consideration alcoholism, psychiatric disorders, or a diagnosis of any disorder for which a treatment could be used as migraine prevention in the previous 1 month or those who could not consume pork-based products (DAO source).

Normal DAO enzyme activity is considered to be a score of 80. In the study, he found that there was a clear correlation between enzyme score and migraine episodes and intensities. Symptom scores rose progressively as enzyme activity dropped below 80 HDU/mL, with scores 50% to 120% higher in the 30-40 HDU/mL range compared with enzyme activity >80 HDU/mL.

Two groups were made and the control group was administered placebos and the other group was given the DAO supplements. The participant dosage was 2 capsules each after breakfast, lunch and dinner. To understand the pain factor, researchers noted the consumption of triptans by the participants. Those who were on placebos consumed 20% more triptans than those on DAO capsules. The diminished triptan use among patients receiving DAO suggests that the compound may have also reduced the intensity of pain during an attack, the researchers suggest.

Dr. Izquierdo also said, “Diamine oxidase supplementation has shown a significant reduction in crisis duration and a tendency toward a reduction in number of crises,” he said. “The treatment is [safe] because we don’t have any adverse events.” (3)

However, to be sure about the outcome of the research, a larger population needs to be studied cutting across ethnic groups and races. At it’s current stage, it is important thus to educate migraineurs of triggers whether they are of food, hunger, exposure to sun, sleep deprivation or weather and environmental conditions.

SOURCES:

  1. Swanson Ultra Daosin Diamine Oxidase; HealthMonthly.co.uk; Web October 2013; http://www.healthmonthly.co.uk/swanson_ultra_daosin_diamine_oxidase
  2. Migraine Attacks Shortened by Diamine Oxidase Supplements; MedScape.com; Web October 2013; http://www.medscape.com/viewarticle/811920
  3. 90% of Migraines Could Be Prevented with Enzyme; Universitat Internacional de Catalunya; Web October 2013; http://www.uic.es/en/news?id_noti=3273

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Cocktail Vitamin Pill To Treat Migraine To Hit Market Soon: Australia

Vitamin Pill Migraine Photo

Now B vitamins and folate combo to improve enzymes connected to migraines (1)

Australian scientists are in the final stages of testing a pill which could help as many as 20% of all migraine sufferers in the country.

It has been noted that migraineurs often have a mutation in the gene called MTHR (or Methylene Tetra-Hydrofolate Reductase). Due to this mutated gene, there exists a deficiency in the enzyme that the gene is responsible for releasing. This enzyme is actually responsible for regulating levels of folate and homocysteine in the body.

But because there are low levels of the enzyme released due to the mutation of the gene, homocysteine levels cannot be controlled efficiently leading to migraines, increased risk of stroke and cardiovascular disorder.

However, the new pill undergoing final stages of trials, is essentially a cocktail of folate and B vitamins and is being seen to improve the functionality of the enzyme that regulates homocysteine levels

As per lead researcher Professor Lyn Griffiths who is also heading a new unit at the Queensland University of Technology that is investigating gene mutations linked to migraines and other chronic illnesses, “A cofactor for the enzyme is vitamins and we’ve done a phase-one and phase-two trial that showed they could make the enzyme work better.” (2)

The final rounds of phase-three trial include some 600 migraine sufferers to test the efficacy of the pill. Though the pill does not claim that it will cure migraines, especially in those without the gene mutation, it does assure that it will reduce both their frequency as well as the severity of the pain in those who do carry the mutation MTHR.

Note:

Migraine sufferers who want to find out if they have the MTHR gene mutation can have a blood sample taken and sent to the university for a $66 DNA test. Professor Griffiths is urging people who suffer from migraine to join the Headache Register at headacheaustralia.org.au. The site allows sufferers to access the latest in migraine news and research, learn about current and upcoming treatment trials and download a Headache Diary to help them manage their disorder.

SOURCES

  1. Image Credit: Young Female Having Headache by imagerymajestic; freedigitalphotos.net; Web September 2013; http://www.freedigitalphotos.net/images/Emotions_g96-Young_Female_Having_Headache_p74906.html
  2. Hopes vitamin pill will ease crippling migraines; News.com.au; Web September 2013; http://www.news.com.au/lifestyle/health/hopes-vitamin-pill-will-ease-crippling-migraines/story-fneuzlbd-1226721310920

 Copyrights apply to this blog. Please refer copyright permissions.