What Should Work, What Might: Migraine Meds Reassessed

ID-100308698

New Studies Re-assesses Migraine Drug Efficacies (1)

Efficacy of migraine drugs was under another new review from researchers who have examined all of the scientific literature available on the treatment as well as followed up on migraine patients and the scientists have come up with what in their view prove effective in acute cases of migraine. Besides these 2 criteria the study was also based on the depth of the published research done on the medications as well as the quantum of studies on them.

The conclusions of the new study at a glance are:

DEEMED EFFECTIVE (LEVEL A) PROBABLY EFFECTIVE (LEVEL B)
TRIPTANS – Sumatriptan, Zolmitriptan, Rizatriptan, Frovatriptan, Almotriptan, Naratriptan, Eletriptan, Avitriptan OPIOID – Codeine+Acetaminophen, Tramadaol+Acetaminophen
Dihydroergotamins
NSAID – Aspirin, Ibuprofen, Naproxen
OPIOID – Butorphanol Nasal Spray
Caffeine with NSAIDS

Findings of the study were published in the January 2015 issue of the medical journal Headache. As per Dr. Stephen Silberstein , professor of neurology and director of the Jefferson Headache Center of Thomas Jefferson University in Philadelphia, “We hope that this assessment of the efficacy of currently available migraine therapies helps patients and their physicians utilize treatments that are the most appropriate for them.” (2)

Based on the study criteria, drugs were thus rated as deemed effective (Level A), probably effective (Level B), possibly effective (Level C). For such medications where the proof was found either inadequate or gave such results which refutes the use of that medicine, was classified as Level U. For a drug to be classified as deemed effective or a Level A drug, the studies done on the drug must be supported by at least well-designed, double-blind, randomized, placebo-controlled clinical trials.  (3)

The American Headache Society will soon be translating the research findings that will aid in providing evidence-based guidelines to clinical practice. In any case, doctors treating migraine patients must consider the individuals on a case to case basis keeping in view the drug side-effects, patient history, costs and drug efficacy.

SOURCES

  1. Image credit: Pills and Capsules – Stock Photo; freedigitalphotos.net; Web February 2015; http://www.freedigitalphotos.net/images/pills-and-capsules-photo-p308698
  2. Study Rates Migraine Medications; WebMD.com; Web February 2015; http://www.webmd.com/migraines-headaches/news/20150120/study-rates-migraine-medications
  3. American Headache Society Provides Updated Assessment of Medications to Treat Acute Migraine; Newswise.com; Web February 2015; http://www.newswise.com/articles/american-headache-society-provides-updated-assessment-of-medications-to-treat-acute-migraine

Copyright apply to this blog. Please refer copyright permissions.

Advertisements

Episode Durations & Number Cutbacks With Diamine Oxidase Pills

swanson-ultra-daosin-30-capsules-300mcg

Diamine Oxidase Supplements May Reduce The Number, Duration, Intensity of Attacks (1)

Researchers have found that taking diamine oxidase supplements significantly reduces the duration of a migraine episode, especially if the migraine has been brought on by food triggers like cheese, caffeine, red wine etc. They have also observed that there exists a mildly indirect relation between to the total number migraine attacks itself in the mid to long run.

Diamine oxidase (DAO) is an amino acid that helps metabolise (break down) histamines released by our bodies. When we eat foods that we are allergic to (because our body cannot handle it’s digestion for any number of reasons specifically lack of appropriate enzymes) then the body perceives the situation as a threat to it’s well being. As a result it begins an immune response. In such as case histamines are released causing the capillary walls to give more access to proteins and white blood cells to engage with the pathogen/trigger/danger. This increase in histamine triggers migraines.

Histamines are also present in certain foods itself that when consumed raise histamine levels of the body and then trigger a migraine. Thus it is obvious that if migraineurs with food or weather triggers are administered an enzyme (such as DAO) that is responsible for the breakdown of histamines, migraine duration and number of attacks would reduce.

According to Joan Izquierdo, MD, from the Faculty of Health Sciences at the International University of Catalonia and the neurology service at Catalonia General Hospital in Barcelona, Spain, who studied men or women between ages 18 to 60 years old with an attack within the previous 6 months, “We diagnosed 137 patients who have a migraine, of who 119 showed deficits of the activity of the enzyme DAO, around 87% of the total patients that we have studied.” (2)

The study did not take into consideration alcoholism, psychiatric disorders, or a diagnosis of any disorder for which a treatment could be used as migraine prevention in the previous 1 month or those who could not consume pork-based products (DAO source).

Normal DAO enzyme activity is considered to be a score of 80. In the study, he found that there was a clear correlation between enzyme score and migraine episodes and intensities. Symptom scores rose progressively as enzyme activity dropped below 80 HDU/mL, with scores 50% to 120% higher in the 30-40 HDU/mL range compared with enzyme activity >80 HDU/mL.

Two groups were made and the control group was administered placebos and the other group was given the DAO supplements. The participant dosage was 2 capsules each after breakfast, lunch and dinner. To understand the pain factor, researchers noted the consumption of triptans by the participants. Those who were on placebos consumed 20% more triptans than those on DAO capsules. The diminished triptan use among patients receiving DAO suggests that the compound may have also reduced the intensity of pain during an attack, the researchers suggest.

Dr. Izquierdo also said, “Diamine oxidase supplementation has shown a significant reduction in crisis duration and a tendency toward a reduction in number of crises,” he said. “The treatment is [safe] because we don’t have any adverse events.” (3)

However, to be sure about the outcome of the research, a larger population needs to be studied cutting across ethnic groups and races. At it’s current stage, it is important thus to educate migraineurs of triggers whether they are of food, hunger, exposure to sun, sleep deprivation or weather and environmental conditions.

SOURCES:

  1. Swanson Ultra Daosin Diamine Oxidase; HealthMonthly.co.uk; Web October 2013; http://www.healthmonthly.co.uk/swanson_ultra_daosin_diamine_oxidase
  2. Migraine Attacks Shortened by Diamine Oxidase Supplements; MedScape.com; Web October 2013; http://www.medscape.com/viewarticle/811920
  3. 90% of Migraines Could Be Prevented with Enzyme; Universitat Internacional de Catalunya; Web October 2013; http://www.uic.es/en/news?id_noti=3273

Copyrights apply to this blog. Please refer copyright permissions.

Endorphins Enable Enhanced Endurance

Hi on a beautiful Sunday morning! I am sitting here by the living room window with my cup of tea and the thought of a workout later this morning brings endorphins to mind. I think this will make a good post topic today. Though I have covered endorphins in my earlier post, (where I spoke of it being a neurotransmitter polypeptide that has similar affect as morphine),  here is a brief on how you could beef up your endorphin stock….

Like I said, a workout is a great way – what with all the Christmas and New Year partying, exercises may have a double benefit now. Any physically exertive activity in the range of 20 minutes or over (continuous), causes the body to release endorphines as a defense to fight pain and stress. So you could look at brisk walks, jogging, running, interval training, swimming, dancing, cycling, hiking, group aerobics, gyming – you get the idea….Every bit counts – you only need to clock 20 + minutes of continuous exertive activity and most mentioned as examples are fun! 

Here’s another you will like – Food. This helps in 2 ways – the chewing motion triggers mild endorphin release in all animals including us.  Second, foods like chilli peppers (Jalapeno, Pablano etc) when added to food help – As the body encounters capsaicin, it releases endorphines to fight the distress and pain. Chocolates or caffeine based foods (though not recommended for migraineurs in a big way) or high calorie foods also help though their workings are different on our system.

In my next post, I shall discuss 8 other ways to boost your capability to fight pain by elevating endorphin levels..Till then…

As Featured On EzineArticles

Copyrights apply on this blog. Refer copyright permissions.

Feel free to leave your feedback on this blog.

Best Regards

Trying Magnesium

About 2 years back, I stumbled upon magnesium’s big role in regulating calcium ion inflow to neuron cells, channelopathy in migraineurs and of course its spiral effect on the all important serotonin and eventually prostaglandin and a whole gamut of things that go on for a migraineur. By the way, migraineurs are generally defecient in magnesium. Run a blood test and find out if you are in this bracket.

In desperation, I calculated the approximate amount of magnesium I was getting from my diet and it was apallingly low! (Incidentally, magnesium absorption is also inhibited by the caffeine and alcohol intake). I started out on magnesium-calcium supplements for a month that gave me RDA values on both (esp magnesium at 400 mg a day). OK, now get this. I had an episode of migraine the following month but it was so much milder than usual. It arrived one day before I was to head out to London. My work didnt have to stop on the day I was travelling out to London. This was a big deal for me, as will be, I am sure, for many, many migraineurs. I would not have been able to do this without the supplements. Ever since, I have made magnesium a part of diet. I do go off it now and then by choice but I usually do take them and benefit from it immensely.

Copyrights apply on this blog. Refer copyright permissions.

Feel free to leave your feedback on this blog.

Best Regards