New drug combines combines a muco-adhesive drug carrier of active DHE with a proprietary nasal powder drug delivery device (1)
A new drug that is poised as a rapidly absorbed chemical in the treatment of acute migraines is now on the horizon. The principal or active chemical in the new drug is dihydroergotamine or DHE.
It is anticipated that DHE which for patenting process is known as TO-2070 will provide a novel and potentially improved approach to treatment of acute migraines in patients. TO-2070 is based on a novel nasal powder drug delivery technology. The technology which is developed by Shin Nippon Biomedical Laboratories (SNBL) combines a muco-adhesive drug carrier with a proprietary nasal powder drug delivery device.
Actually DHE is a well-known treatment for treatment of acute migraines and is being used in the US since 1946, however its delivery via the liquid nasal spray route, the subcutaneous route, via intramuscular injections or intravenous shots is hindered by inconvenient administration regimen, slow onset of relief, inconsistent absorption, post-nasal drip and bitter taste. DHE delivery via the pulmonary inhalation method has still not obtained a nod from FDA.
As per the preclinical data this new drug could offer a considerable range of benefits to the migraineur. Such benefits as are not provided by the currently available delivery methods such as injections, pulmonary inhalation etc which prove more inconvenient as well as invasive by nature. (2)
Both Transcept and SNBL have announced that they have entered into an exclusive global licensing agreement. Transcept will pay SNBL an upfront fee, charges through the developmental milestones of the drug as well as following launch and commercialization. This deal will provide Transcept with an advanced nasal powder delivery device and preclinical and clinical services to support the development of TO-2070.
According to Alan Rapoport, M.D., Clinical Professor of Neurology at the David Geffen School of Medicine at UCLA, Los Angeles, CA, and President of the International Headache Society, “DHE has proven to be an excellent treatment for many of the migraine patients who have tried it. This medication can work quickly depending on how it is administered, provides long-lasting relief, has demonstrated a low migraine recurrence rate and can be effectively administered late in the migraine process. Despite these important advantages, the therapeutic impact of DHE has been somewhat limited by challenges associated with the effective delivery of the drug. With this in mind, a novel delivery system that enables the administration of DHE in a convenient way and offers patients rapid and sustained migraine relief, would represent an important advance in the treatment of migraine.” (3)
- Image Credits: File:Dihydroergotamine.svg; Wikipedia.com – Wikipmedia Commons; Web September 2013; http://en.wikipedia.org/wiki/File:Dihydroergotamine.svg
- Transcept, SNBL Sign Global Licensing Deal For Advanced Acute Migraine Treatment; RTT News; Web September 2013; http://www.rttnews.com/2193740/transcept-snbl-sign-global-licensing-deal-for-advanced-acute-migraine-treatment.aspx?type=bn
- Transcept And Shin Nippon Biomedical Laboratories Announce Global Licensing Agreement For Advanced Acute Migraine Treatment; Market Watch – The Wall Street Journal; Web September 2013; http://www.marketwatch.com/story/transcept-and-shin-nippon-biomedical-laboratories-announce-global-licensing-agreement-for-advanced-acute-migraine-treatment-2013-09-25
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